Lands around Grittleton were owned by the monks of Glastonbury Abbey in Anglo-Saxon times. During the 16th century the clergy were in turn Catholic or protestant, according to which monarch was on the throne. Records list clergymen as far back as 1269, and Rev. Jackson, in his book, suggests the nave of the church dates from around 1380, with the tower at a later date.
In 1667 the Church Wardens were John Jaques and John Bonnet of Foscote, and repairs to the tower in 1672 cost 8/-, eight shillings (40p.) the Church Wardens in 1799 are recorded as Antony Allen and Isaac Turk.
The chancel was rebuilt in 1805 by Rector Burne, who, at his own expense, added a new aisle and porch on the south side. The cost was £1,000, and the architect was John Pinch. A font of Painswick stone was installed. However, by 1862 the exterior of the tower needed repair. During the period 1805-10 various pieces of silver were donated to the church.