The Wesleyan Methodists originally met in a cottage near the Priory. A building fund for a new chapel was started in 1868 and a site near the town bridge and the Priory was bought for £12.10 shillings (£12.50). The chapel was built by 1870 at a total cost of £372. The congregation had paid all its debts for this building by 1874 and was in a flourishing state. The chapel was renovated in 1903 and was generally known as the 'Priory church' to distinguish it from the Primitive Methodists' 'Calcutt Street church'. In the 20th century the two groups of Methodists co-operated in many ways and after the First World War held joint mid-week services with the Congregationalists.
In 1936 a trial period of amalgamation with the Primitive Methodists was carried out with the congregations meeting in each other's churches on alternate Sundays. This continued until the actual union of the two congregations on 20th June 1938, an event preceded by church sevices on Sunday 19th June. The new congregation, known as Cricklade Methodist Church, met at the Calcutt Street church while the 'priory' church was used for a united Sunday School. During the Second World War the 'Priory' church was lent to the local Civil Defence force and the Sunday School moved to Calcutt Street. After the war the Priory was taken over by Wiltshire County Council Education Department and the chapel was used as a schoolroom.