This was founded in 1871 by Lady Elizabeth Herbert of Lea, patron of the Roman Catholic church of St. Osmund. It was conducted by the Sisters of Charity of St. Vincent de Paul and was for 100 poor, or neglected children, whose families were unable or unwilling to look after them. Lady Herbert bought St. Elizabeth's, now 131 Exeter Street, and this was used as a girls' boarding school where the girls were cared for and taught occupations, mainly to prepare them for going into domestic service.In the 1870s there were 50 girls but this number soon grew to 125 in the home and school. New school buildings and dormitories had to be built and a chapel was erected.
Later a new laundry was constructed and this provided a valuable source of income as the pupils operated it by taking in laundry from the city. New legislation caused the independent school to close in 1924 and its premises were used for St. Osmund's School. The St. Elizabeth's Home continued in the main building as a children's home and later as a private hostel for girls under the jurisdiction of the Board of Education. This later moved to Fowler's Hill where it continued until 1982 when the Sisters left Salisbury.