Originally set up by the vicar's wife, Mrs Guthrie, for the training of female sevants. The school was built off Wood Street in 1854 and was an off shoot of the National Society. By 1858 there were classrooms for both infants and older children and there were 80-90 pupils. A new classroom was added in 1899 and the school was again enlarged in 1903. With the formation of Calne Junior School in 1930 the Guthrie School became the infants' school for the town. In 1959 extra classrooms were built in Bryan's Close Road and in 1964 the whole school moved to a new building in the north of the town. It is now an infants' school and and has merged with the infants' department of the adjacent St. Dunstan's School.